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Buerger, K., Ewers, M., Pirttila, T., Zinkowski, R., Alafuzoff, I., Teipel, S.J., DeBernardis, J., Kerkman, D., McCulloch, C., Soininen, H., and Hampel, H. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer’s disease. Brain. 129:3035-3041, 2006.
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+ Summary (click to view)
This study demonstrates that the levels of CSF ptau-231 taken while the patient was living correlates with the neurofibrillary pathology observed in the brain upon autopsy. This study consisted of 26 autopsy confirmed AD patients.
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Buerger, K., Alafuzoff, I., Ewers, M., Pirttila, T., Zinkowski, R., and Hampel, H. Letter to the editor. No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer disease. Brain. 130 (Pt 10): e82, 2007.
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+ Summary (click to view)
This is a short note to the editor that describes the finding that CSF pTau181 measured using the Innogenetics assay does not correlated to scores of neurofibrillary tangles (NFTs) and neuritic plaques (NP ) found in brain at autopsy. Furthermore, CSF pTau181 is not correlated with levels of pTau181 measured in brain homogenates. This is in contrast to our recent report in Brain that positive correlations were found for CSFpTau231 in the same study group, on the same material, applying the same statistical analyses. In this report CSF pTau231 concentrations were correlated with scores of NFTs, NP’s in the frontal cortex and the amount of pTau 231 measured in brain homogenates from the same autopsy brains.
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